Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes

被引：108

作者：

Kim, Chulhong ^{[1
]}

Erpelding, Todd N. ^{[2
]}

Maslov, Konstantin ^{[1
]}

Jankovic, Ladislav ^{[2
]}

Akers, Walter J. ^{[3
,4
]}

Song, Liang ^{[1
]}

Achilefu, Samuel ^{[3
,4
]}

Margenthaler, Julie A. ^{[5
]}

Pashley, Michael D. ^{[2
]}

Wang, Lihong V. ^{[1
]}

机构：

[1] Washington Univ, Opt Imaging Lab, Dept Biomed Engn, St Louis, MO 63130 USA

[2] Philips Res N Amer, Briarcliff Manor, NY 10510 USA

[3] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63108 USA

[4] Washington Univ, Opt Radiol Lab, Dept Biophys, St Louis, MO 63108 USA

[5] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 04期

基金：

美国国家卫生研究院;

关键词：

image-guided needle biopsy; photoacoustic imaging; ultrasound array system; sentinel lymph node biopsy; SYSTEM; MODEL;

D O I：

10.1117/1.3469829

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles for pulsed laser light delivery enables photoacoustic image-guided insertion of a needle into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong photoacoustic contrast of the needle is achieved. After subcutaneous injection of the dye in the left forepaw, sentinel lymph nodes are easily detected, in vivo and in real time, beneath 2-cm-thick chicken breast overlaying the axillary region. ICG uptake in axillary lymph nodes is confirmed with fluorescence imaging both in vivo and ex vivo. These results demonstrate the clinical potential of this handheld photoacoustic system for facile identification and needle biopsy of sentinel lymph nodes for cancer staging and metastasis detection in humans. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3469829]

引用

页数：4

共 13 条

[1]

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[2]

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