Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-β

被引:142
作者
Kee, BL [1 ]
Rivera, RR [1 ]
Murre, C [1 ]
机构
[1] Univ Calif San Diego, Dept Biol MC0366, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/85303
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
E proteins function in many developmental processes and are essential for the formation of lymphocyte progenitors. However, it is not known whether E proteins regulate lymphocyte survival, proliferation or differentiation or how their activity is regulated during lymphocyte development. We show here a role for Id3, an inhibitor of E protein activity, in the induction of apoptosis and growth arrest, Id3 is induced in response to transforming growth factor beta (TGF-beta), a pleiotropic cytokine that inhibits the growth and survival of normal and transformed lymphocyte progenitors. In the absence of ld3, the response of lymphocyte progenitors to TGF-beta is perturbed, which indicates that Id3 is a mediator of this response. Our data show a key role for E proteins in lymphocyte survival and link the activity of E proteins, and their antagonists, to members of the TGF-beta family of cytokines.
引用
收藏
页码:242 / 247
页数:6
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