Elucidation of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis:: straightforward syntheses of enantiopure 1-deoxy-D-xylulose from pentose derivatives

被引：9

作者：

Hoeffler, JF ^{[1
]}

Grosdemange-Billiard, C ^{[1
]}

Rohmer, M ^{[1
]}

机构：

[1] Univ Strasbourg 1, CNRS, Inst Le Bel, F-67070 Strasbourg, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 17期

关键词：

1-deoxy-D-xylulose; methylerythritol phosphate; biosynthesis; isoprenoids; 2-C-methyl-D-erythritol phosphate; terpenoids;

D O I：

10.1016/S0040-4039(01)00376-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optically pure I-deoxy-D-xylulose, a key metabolite for feeding experiments in the methylerythritol phosphate pathway for isoprenoid biosynthesis, is conveniently synthesised from 1,2-O-isopropylidene-alpha -D-xylofuranose or from D-arabinose. This renders labelling with hydrogen isotopes possible. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3065 / 3067

页数：3

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