Function of the zinc-finger transcription factor SNAI2 in cancer and development

被引：151

作者：

Cobaleda, Cesar ^{[1
]}

Perez-Caro, Maria ^{[1
]}

Vicente-Duenas, Carolina ^{[1
]}

Sanchez-Garcia, Isidro ^{[1
]}

机构：

[1] Univ Salamanca, CSIC, IBMCC, Expt Therapeut & Translat Oncol Program, Salamanca 37007, Spain

来源：

ANNUAL REVIEW OF GENETICS | 2007年 / 41卷

关键词：

cancer stem cells; stem cells; stem cell niche; biomarkers; mouse models; experimental therapeutics and translational oncology;

D O I：

10.1146/annurev.genet.41.110306.130146

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Elucidation of the molecular mechanisms that underlie disease development is still a tremendous challenge for basic science, and a prerequisite to the development of new and disease-specific targeted therapies. This review focuses on the function of SNAI2, a member of the Snail family of zinc-finger transcription factors, and discusses its possible role in disease development. SNAI2 has been implicated in diseases of melanocyte development and cancer in humans. Many malignancies arise from a rare population of cells that alone have the ability to self-renew and sustain the tumor (i.e., cancer stem cells). SNAI2 controls key aspects of stem cell function in mouse and human, suggesting that similar mechanisms control normal development and cancer stem cell properties. These insights are expected to contribute significantly to the genetics of cancer and to the development of both cancer therapy and new methods for assessing treatment efficacy.

引用

页码：41 / 61

页数：21

共 95 条

[1] Proximal chromosome 8q deletion in a boy with femoral bifurcation and other multiple congenital anomalies [J].