Intracellular assembly of VLDL - Two major steps in separate cell compartments

被引：114

作者：

Olofsson, SO

Stillemark-Billton, P

Asp, L

机构：

[1] Univ Gothenburg, Dept Biochem Med, SE-40530 Gothenburg, Sweden

[2] Univ Gothenburg, Wallenberg Lab Cardiovasc Res, SE-40530 Gothenburg, Sweden

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S1050-1738(01)00071-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The assembly of very low-density lipoproteins (VLDL) occurs in two major steps. The first step is the co- and post-translational lipidation of apoB, forming pre-VLDL in the rough endoplasmic reticulum. The microsomal triglyceride transfer protein catalyzes this step. In the second step pre-VLDL is converted to bona fide VLDL in a smooth membrane compartment. This step depends on ADP-ribosylation factor 1 and its activation of phospholipase D. (Trends Cardiovasc Med 2000; 10:338-345). (C) 2001, Elsevier Science Inc.

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页码：338 / 345

页数：8

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