The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus

被引：108

作者：

Morales, M ^{[1
]}

Battenberg, E ^{[1
]}

deLecea, L ^{[1
]}

Bloom, FE ^{[1
]}

机构：

[1] Scripps Res Inst, DEPT MOL BIOL, LA JOLLA, CA 92037 USA

来源：

BRAIN RESEARCH | 1996年 / 731卷 / 1-2期

关键词：

serotonin; interneuron; dentate gyrus; tenia tecta; septum; amygdala;

D O I：

10.1016/S0006-8993(96)00557-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We used in situ hybridization and immunocytochemistry to investigate the presence of GABA in neurons that express the type 3 serotonin receptor (5-HT(3)R). Quantitative analysis indicated that more than 90% of 5-HT(3)R expressing cells are GABAergic in the neocortex and hippocampus. The co-existence of 5-HT(3)R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT(3)R, can affect GABA release and suggests the participation of 5-HT(3)R in the inhibitory regulation of forebrain neurons.

引用

页码：199 / 202

页数：4

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