Liver protective effects of Morinda citrifolia (Noni)

被引：80

作者：

Wang, Mian-Ying ^{[1
]}

Nowicki, Diane ^{[1
]}

Anderson, Gary ^{[1
]}

Jensen, Jarakae ^{[2
]}

West, Brett ^{[2
]}

机构：

[1] Univ Illinois, Coll Med, Dept Pathol, Rockford, IL 61107 USA

[2] Morinda Holdings Inc, Res & Dev, Provo, UT 84604 USA

来源：

PLANT FOODS FOR HUMAN NUTRITION | 2008年 / 63卷 / 02期

关键词：

Morinda citrifolia; Noni; liver protection; carbon tetrachloride;

D O I：

10.1007/s11130-008-0070-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl(4)) in female Sprague-Dawley (SD) rats. Liver damage (micro-centrilobular necrosis) was observed in animals pretreated with 20% placebo (drinking water) + CCl(4). However, pretreatment with 20% Noni juice in drinking water + CCl(4) resulted in markedly decreased hepatotoxic lesions. Furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were significantly lower in the Noni group than the placebo group. In a correlative time-dependent study, one dose of CCl(4) (0.25 mL/kg in corn oil, p.o.) in female SD rats, pretreated with 10% placebo for 12 days, caused sequential progressive hepatotoxic lesions over a 24 h period, while a protective effect from 10% Noni juice pretreatment was observed. These results suggest that Noni juice is effective in protecting the liver from extrinsic toxin exposure.

引用

页码：59 / 63

页数：5

共 10 条

[1]

Free radical scavenging and hepatoprotective actions of the medicinal herb, Crassocephalum crepidioides from the Okinawa Islands [J].

Aniya, Y ;

Koyama, T ;

Miyagi, C ;

Miyahira, M ;

Inomata, C ;

Kinoshita, S ;

Ichiba, T .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2005, 28 (01) :19-23

[2]

BRATTIN W J, 1985, Journal of Free Radicals in Biology and Medicine, V1, P27, DOI 10.1016/0748-5514(85)90026-1

[3]

[EFSA] European Food Safety Authority, 2006, EFSA J, V376, P1

[4]

VITAMIN-E THERAPY OF ACUTE CCL4-INDUCED HEPATIC-INJURY IN MICE IS ASSOCIATED WITH INHIBITION OF NUCLEAR-FACTOR-KAPPA-B BINDING [J].

LIU, SL ;

ESPOSTI, SD ;

YAO, T ;

DIEHL, AM ;

ZERN, MA .

HEPATOLOGY, 1995, 22 (05) :1474-1481

[5]

Tutorials in clinical research: VII. Understanding comparative statistics (Contrast) - Part B: Application of T-test, Mann-Whitney U, and chi-square [J].

Neely, JG ;

Hartman, JM ;

Forsen, JW ;

Wallace, MS .

LARYNGOSCOPE, 2003, 113 (10) :1719-1725

[6]

RECKNAGE RO, 1967, PHARMACOL REV, V19, P145

[7]

SEIFERT WF, 1995, LIVER, V15, P1

[8]

Cancer preventive effect of Morinda citrifolia (Noni) [J].

Wang, MY ;

Su, C .

CANCER PREVENTION: MOLECULAR MECHANISMS TO CLINICAL APPLICATIONS, 2001, 952 :161-168

[9]

A safety review of noni fruit juice [J].

West, B. J. ;

Jensen, C. J. ;

Westendorf, J. ;

White, L. D. .

JOURNAL OF FOOD SCIENCE, 2006, 71 (08) :R100-R106

[10]

Noni juice is not hepatotoxic [J].

West, Brett J. ;

Jensen, C. Jarakae ;

Westendorf, Johannes .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (22) :3616-3619

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