Synthesis of 2,6-bis(4R-trialkylsiloxymethyloxazolinyl)pyridines and their use in catalytic asymmetric 1,3-dipolar cycloaddition reactions of nitrones and activated alkenes

被引：44

作者：

Iwasa, S ^{[1
]}

Tsushima, S ^{[1
]}

Shimada, T ^{[1
]}

Nishiyama, H ^{[1
]}

机构：

[1] Toyohashi Univ Technol, Sch Mat Sci, Aichi 4418580, Japan

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 38期

关键词：

nitrone; 1,3-dipolar cycloaddition; pybox; nickel; Lewis acid; asymmetric catalyst; oxazolidinone;

D O I：

10.1016/S0040-4039(01)01315-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1,3-Dipolar cycloaddition reaction of aromatic nitrones with 3-alkenoyl-2-oxazolidinones in the presence of a chiral 2,6-bis(4R-trialkylsiloxymethyloxazolinyl)pyridine/Ni(II) system proceeds smoothly with high enantioselectivity in up to 99% ee. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：6715 / 6717

页数：3

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