Synthesis and biological activity of a ferrocenyl ligand derived from thiophenol and its coordination with some transition metals

被引：9

作者：

Abd-Elzaher, Mokhles M. ^{[1
]}

Moustafa, Samia A. ^{[1
]}

Mousa, Hanan A. ^{[1
]}

Labib, Ammar A. ^{[1
]}

机构：

[1] Natl Res Ctr, Dept Inorgan Chem, Cairo, Egypt

来源：

MONATSHEFTE FUR CHEMIE | 2012年 / 143卷 / 06期

关键词：

Bioinorganic chemistry; Ligands; Metallocenes; Schiff bases; Transition metal compounds; AMINO-ACIDS; DERIVATIZING REAGENTS; ZINC(II) COMPLEXES; SCHIFF-BASES; X-RAY; PEPTIDES; CHEMISTRY; NICKEL(II); COBALT(II); PROTEINS;

D O I：

10.1007/s00706-011-0685-1

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The new ferrocenyl ligand 1,1'-bis(2,3-dihydro-2-methylbenzo[]thiazol-2-yl)ferrocene was prepared at room temperature from the condensation reaction of 2-aminothiophenol with 1,1'-diacetylferrocene followed by intramolecular Michael-type addition. The prepared ligand forms 1:1 complexes with manganese(II), cobalt(II), nickel(II), copper(II), and zinc(II) in good yield. Characterization of the ligand and its complexes was carried out using IR, H-1 and C-13 NMR, electronic absorption, mass spectra, magnetic susceptibility, molar conductance, and elemental analysis. Biological activity of the ligand and its complexes was assessed against , , , , , and . The results indicated that the ligand is biologically active but the complexes are more active. The Zn and Cu complexes exhibited biological activity comparable to that of chloramphenicol (commercial broad-spectrum antibiotic).

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页码：909 / 915

页数：7

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