Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction

被引：58

作者：

Baldoli, C

Maiorana, S

Licandro, E

Zinzalla, G

Perdicchia, D

机构：

[1] Univ Milan, CNR, Ist Sci & Tecnol Mol, I-20133 Milan, Italy

[2] Univ Milan, Dipartimento Chim Organ, I-20133 Milan, Italy

[3] Univ Milan, CISI, Ctr Eccellenza, I-20133 Milan, Italy

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 24期

关键词：

D O I：

10.1021/ol026994a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

graphic Ugi condensation was used to synthesize the first examples of chiral racemic Ar.Cr(CO)(3) labeled peptide nucleic acid (PNA) monomers bearing the organometallic moiety linked to the alpha-carbon of the glycine unit.

引用

页码：4341 / 4344

页数：4

共 25 条

[1] [Anonymous], ADV METAL ORGANIC CH
[2] [Anonymous], 1995, Comprehensive Organometallic Chemistry II
[3] Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives:: stereoselective synthesis of (R)-(-)-baclofen
Baldoli, C
Maiorana, S
Licandro, E
Perdicchia, D
Vandoni, B
[J]. TETRAHEDRON-ASYMMETRY, 2000, 11 (09) : 2007 - 2014
[4] THE HIGHLY STEREOSELECTIVE CONVERSION OF N,N-DIMETHYLAMPHETAMINE INTO N-METHYLPSEUDOEPHEDRINE - A MIMIC OF THE ENZYME MEDIATED STEREOSPECIFIC BENZYLIC HYDROXYLATION OF 2-ARYLETHYLAMINES
BLAGG, J
DAVIES, SG
[J]. TETRAHEDRON, 1987, 43 (19) : 4463 - 4471
[5] Dömling A, 2000, ANGEW CHEM INT EDIT, V39, P3168, DOI 10.1002/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO
[6] 2-U
[7] A novel method to highly versatile monomeric PNA building blocks by multi component reactions
Dömling, A
Chi, KZ
Barrère, M
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (19) : 2871 - 2874
[8] SYNTHESIS OF PEPTIDE NUCLEIC-ACID MONOMERS CONTAINING THE 4 NATURAL NUCLEOBASES - THYMINE, CYTOSINE, ADENINE, AND GUANINE AND THEIR OLIGOMERIZATION
DUEHOLM, KL
EGHOLM, M
BEHRENS, C
CHRISTENSEN, L
HANSEN, HF
VULPIUS, T
PETERSEN, KH
BERG, RH
NIELSEN, PE
BUCHARDT, O
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (19) : 5767 - 5773
[9] Transition metal labels on peptide nucleic acid (PNA) monomers
Hess, A
Metzler-Nolte, N
[J]. CHEMICAL COMMUNICATIONS, 1999, (10) : 885 - 886
[10] Postcondensation modifications of Ugi four-component condensation products: 1-Isocyanocyclohexene as a convertible isocyanide. Mechanism of conversion, synthesis of diverse structures, and demonstration of resin capture
Keating, TA
Armstrong, RW
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (11) : 2574 - 2583

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