Identification of a new DQB1 allele that appears to have been generated by an interallelic sequence exchange

被引：2

作者：

Perrier, P ^{[1
]}

Reveillere, C ^{[1
]}

Andre-Botte, C ^{[1
]}

Schuhmacher, A ^{[1
]}

机构：

[1] CHU, Lab Histocompatibil, F-54511 Vandoeuvre Les Nancy, France

来源：

TISSUE ANTIGENS | 2000年 / 56卷 / 06期

关键词：

DNA sequencing; gene conversion; HLA-DQB1; reverse dot blot hybridization;

D O I：

10.1034/j.1399-0039.2000.560612.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The study reports the molecular characterization of a new DQB1 variant initially detected by unusual sequence-specific oligonucleotide (SSO) hybridization patterns in one Caucasoid individual. This new allele is identical to DQB1*0501 except for two silent nucleotide substitutions at codons 49 (GCA --> GCG) and 77 (AGG --> AGA). Compared with DQB1*0502 it differs in three nucleotides at codon 57 changing AGC (encoding Ser) to GTT (encoding Val). Considering the paternal genotype, it appears this new allele might have been generated by an interallelic sequence exchange between the two paternal DQB1 alleles.

引用

页码：556 / 559

页数：4

共 17 条

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