The Physiological Actions of Isoflavone Phytoestrogens

被引:175
作者
Pilsakova, L. [1 ]
Riecansky, I. [1 ,2 ]
Jagla, F. [1 ]
机构
[1] Slovak Acad Sci, Inst Normal & Pathol Physiol, Sienkiewiczova 1, Bratislava 81371, Slovakia
[2] Univ Vienna, Fac Psychol, Inst Clin Biol & Differential Psychol, A-1010 Vienna, Austria
关键词
Isoflavones; Estradiol; Estrogen receptor; Sex hormones; Steroid hormones; Hormonal regulation; Phytopharmaceuticals; RED WINE POLYPHENOLS; NITRIC-OXIDE SYNTHASE; GENISTEIN ALTERS GROWTH; ESTROGEN-RECEPTOR-ALPHA; CORONARY-HEART-DISEASE; IMPROVE PLASMA-LIPIDS; SOY PROTEIN ISOLATE; POSTMENOPAUSAL WOMEN; BLOOD-PRESSURE; BREAST-CANCER;
D O I
10.33549/physiolres.931902
中图分类号
Q4 [生理学];
学科分类号
071003 [生理学];
摘要
Isoflavones are a subgroup of phytoestrogens, natural plant substances with structure similar to 17-beta-estradiol and capable of binding to estrogen receptors (ERs). Isoflavones possess higher affinity to ER beta than to ER alpha and may have a potency to activate both genomic and non-genomic estrogen signaling pathways. In addition, isoflavones interact with the metabolism of steroid hormones. Therefore, the actions of isoflavones are rather complex and may be related to large number of factors, which are not satisfactorily identified yet. Recently, isoflavones have come into focus of interest due to several reports about their positive effect on human health, in particular prevention of hormone-dependent cancers, cardiovascular diseases, osteoporosis, adverse menopausal manifestations and age-related cognitive decline. Isoflavones may bring new insights into the mechanisms of physiological regulations and increase the possibilities of medical interventions.
引用
收藏
页码:651 / 664
页数:14
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