A Polymorphism Near IL28B Is Associated With Spontaneous Clearance of Acute Hepatitis C Virus and Jaundice

被引：270

作者：

Tillmann, Hans L. ^{[1
]}

Thompson, Alex J.

Patel, Keyur

Wiese, Manfred

Tenckhoff, Hannelore ^{[4
]}

Nischalke, Hans D. ^{[5
]}

Lokhnygina, Yuliya

Kullig, Ulrike ^{[6
]}

Goebel, Uwe

Capka, Emanuela ^{[7
]}

Wiegand, Johannes ^{[4
]}

Schiefke, Ingolf ^{[8
]}

Guethoff, Wolfgang ^{[9
]}

Gruenfreiff, Kurt

Koenig, Ingrid

Spengler, Ulrich ^{[5
]}

McCarthy, Jeanette ^{[2
]}

Shianna, Kevin V. ^{[3
]}

Goldstein, David B. ^{[3
]}

McHutchison, John G.

Timm, Joerg ^{[10
]}

Nattermann, Jacob ^{[5
]}

机构：

[1] Duke Univ, Duke Clin Res Inst, Div Gastroenterol, GI Hepatol Res Program, Durham, NC 27706 USA

[2] Duke Univ, Inst Genom Sci & Policy, Ctr Genom Med, Durham, NC USA

[3] Duke Univ, Ctr Human Genome Variat, Durham, NC USA

[4] Univ Leipzig, Klin & Poliklin Gastroenterol & Rheumatol, Leipzig, Germany

[5] Univ Bonn, Dept Internal Med, D-5300 Bonn, Germany

[6] Krankenhaus Dresden Friedrichstadt, Med Klin 3, Dresden, Germany

[7] Klinikum Chemnitz, Med Klin 2, Chemnitz, Germany

[8] Klinikum St Georg, Leipzig, Germany

[9] Klinikum Ernst Von Bergmann, Potsdam, Germany

[10] Univ Klin Essen, Inst Virol, Essen, Germany

来源：

GASTROENTEROLOGY | 2010年 / 139卷 / 05期

基金：

英国医学研究理事会;

关键词：

Chronic Hepatitis C Virus Infection; Liver; Genetic Variance; Prediction; SINGLE-SOURCE OUTBREAK; GENETIC-VARIATION; AMERICAN PATIENTS; RIBAVIRIN; PEGINTERFERON; MULTICENTER; GENOTYPE-1; INFECTION; GERMANY; HOST;

D O I：

10.1053/j.gastro.2010.07.005

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: A single nucleotide polymorphism (SNP) upstream of the IL28B gene has been associated with response of patients with chronic hepatitis C to therapy with pegylated interferon and ribavirin and also with spontaneous clearance of acute hepatitis C in a heterogeneous population. We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population. METHODS: We analyzed the SNP rs12979860 in 190 women from the German anti-D cohort (infected with HCV genotype 1b via contaminated rhesus prophylaxis) and its association with spontaneous clearance. Clinical data were available in 136 women with acute infection who were also evaluated for IL28B genotype. Based on results of a TaqMan polymerase chain reaction assay, the rs12979860 SNP genotypes studied were C/C, C/T, or T/T. RESULTS: Spontaneous clearance was more common in patients with the C/C genotype (43/67; 64%) compared with C/T (22/90; 24%) or T/T (2/33; 6%) (P < .001). Jaundice during acute infection was more common among patients with C/C genotype (32.7%) than non-C/C patients (with C/T or T/T) (16.1%; P = .032). In C/C patients, jaundice during acute infection was not associated with an increased chance of spontaneous clearance (56.3%) compared with those without jaundice (60.6%). In contrast, in non-C/C patients, jaundice was associated with a higher likelihood of spontaneous clearance (42.9%) compared with those without jaundice (13.7%). CONCLUSIONS: The SNP rs12979860 upstream of IL28B is associated with spontaneous clearance of HCV. Women with the C/T or T/T genotype who did not develop jaundice had a lower chance of spontaneous clearance of HCV infection.

引用

页码：1586 / +

页数：8