CuH-catalyzed asymmetric conjugate reductions of acyclic enones

被引：133

作者：

Lipshutz, BH ^{[1
]}

Servesko, JM ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 39期

关键词：

conjugate reductions; copper hydride; enones; hydrosilylation; phosphane ligands;

D O I：

10.1002/anie.200352313

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A powerful new reaction has been developed for the asymmetric 1, 4-reduction of prochiral enones (see scheme). The key ingredients in this exceedingly mild and straightforward procedure are catalytic quantities of CuH, a readily available nonracemic phosphane ligand such as that shown, and inexpensive polymethyl-hydrosiloxane (PMHS) as the stoichiometric source of hydride.

引用

页码：4789 / 4792

页数：4

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