Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients

被引：35

作者：

Phillips, DH ^{[1
]}

Hewer, A ^{[1
]}

Grover, PL ^{[1
]}

Poon, GK ^{[1
]}

Carmichael, PL ^{[1
]}

机构：

[1] CRC, CTR CANC THERAPEUT, INST CANC RES, SUTTON SM2 5NG, SURREY, ENGLAND

来源：

CARCINOGENESIS | 1996年 / 17卷 / 05期

关键词：

D O I：

10.1093/carcin/17.5.1149

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA from white blood cells of seven women receiving tamoxifen as adjuvant therapy for breast cancer and of three women who served as healthy controls was analysed for the presence of tamoxifen-DNA adducts using P-32-postlabelling with a Limit of detection of 8 adducts/10(10) nucleotides. No postlabelled adducts with the chromatographic properties of known tamoxifen-DNA adducts were detected in any of the samples, It is concluded that at therapeutic levels of exposure there is no significant formation of DNA adducts by tamoxifen or its metabolites in circulating white blood cells.

引用

页码：1149 / 1152

页数：4

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