共 21 条
[21]
Van Ark-Otte J, 1998, ONCOL REP, V5, P249
Comparing the relationship of Taxol-based chemotherapy response with P-glycoprotein and lung resistance-related protein expression in non-small cell lung cancer
被引：47
作者：
Chiou, JF
Liang, JA
Hsu, WH
Wang, JJ
Ho, ST
Kao, A
机构：
[1] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan
[2] Taipei Med Univ Hosp, Ctr Canc, Taipei, Taiwan
[3] Taipei Med Univ Hosp, Dept Radiat Oncol, Taipei, Taiwan
[4] China Med Univ Hosp, Dept Radiat Therapy & Oncol, Taichung 404, Taiwan
[5] China Med Univ Hosp, Dept Internal Med, Div Pulm Crit Care Med, Taichung 404, Taiwan
[6] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan
[7] Tri Serv Gen Hosp, Dept Anesthesiol, Taipei, Taiwan
来源：
关键词：
non-small cell lung cancer;
Taxol;
P-glycoprotein;
lung resistance protein expression;
D O I：
10.1007/s00408-003-1029-7
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Our aim was to compare Taxol-based chemotherapy response of non-small cell lung cancer (NSCLC) with P-glycoprotein (Pgp) or lung resistance protein expression (LRP). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp and LPR expressions in 40 patients with advanced NSCLC before Taxol-based chemotherapy. The chemotherapy response was evaluated by clinical and radiological methods in the third month after completion of treatment. No significant differences of prognostic factors (age, sex, body weight loss, performance status, tumor size, tumor stage, and tumor cell type) were found between the 20 patients with good and the 20 patients with poor responses. The incidence difference of positive Pgp expressions between good and poor responses was significant, however, the difference of LRP expression was not. We concluded that Taxol-based chemotherapy response of patients with NSCLC was related to Pgp but not LPR expression.
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页码：267 / 273
页数：7
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