N-nitration of secondary amines with 4-chloro-5-methoxy-2-nitropyridazin-3-one

被引：32

作者：

Park, YD

Kim, HK

Kim, JJ

Cho, SD

Kim, SK

Shiro, M

Yoon, YJ ^{[1
]}

机构：

[1] Gyeongsang Natl Univ, Dept Chem, Chinju 660701, South Korea

[2] Gyeongsang Natl Univ, Res Inst Nat Sci, Chinju 660701, South Korea

[3] Changwon Natl Univ, Res Inst Nat Sci, Dept Biol & Chem, Chang Won 641773, South Korea

[4] Chinju Natl Univ Educ, Dept Sciece Educ, Chinju 660756, South Korea

[5] Rigaku Corp, Akishima, Tokyo 1968666, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 23期

关键词：

D O I：

10.1021/jo0301503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Nitration of 4-chloro-5-substituted-pyridazin-3-one with copper nitrate trihydrate in acetic anhydride gave the corresponding 4-chloro-2-nitro-5-substituted-pyridazin-3-one. 4-Chloro-5-alkoxy-2-nitropyridazin-3-ones such as 5-methoxy (2b) and 5-ethoxy (2d) derivatives showed excellent nitro group transfer potentiality. N-Nitration of some secondary amines with 2b gave the corresponding N-nitramines under mild neutral condition in good yields.

引用

页码：9113 / 9115

页数：3

共 27 条

[1] ELECTROPHILIC TETRAALKYLAMMONIUM NITRATE NITRATION .1. CONVENIENT NEW ANHYDROUS NITRONIUM TRIFLATE SYNTHESIS AND IN-SITU HETEROCYCLIC N-NITRATION [J].