Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp K04-0144 -: I.: Taxonomy, fermentation, isolation and structural elucidation

被引：37

作者：

Fukumoto, Atsushi ^{[1
,2
]}

Kim, Yong-Pil ^{[3
]}

Matsumoto, Atsuko ^{[3
]}

Takahashi, Yoko ^{[1
,2
]}

Shiomi, Kazuro

Tomoda, Hiroshi ^{[3
]}

Omura, Satoshi ^{[1
,2
,3
]}

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088641, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 01期

关键词：

cyslabdan; imipenem potentiator; methicillin-resistant; Staphylococcus aureus; MRSA; structural elucidation;

D O I：

10.1038/ja.2008.101

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetyleysteine via thioether linkage.

引用

页码：1 / 6

页数：6

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