Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, produced by Streptomyces sp K04-0144 -: II.: Biological activities

被引：46

作者：

Fukumoto, Atsushi ^{[1
,2
]}

Kim, Yong-Pil ^{[3
]}

Hanaki, Hideaki ^{[3
]}

Shiomi, Kazuro ^{[1
,2
]}

Tomoda, Hiroshi ^{[3
]}

Omura, Satoshi ^{[1
,2
,3
]}

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Univ, Sch Pharm, Minato Ku, Tokyo 1088641, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2008年 / 61卷 / 01期

关键词：

cyslabdan; imipenem potentiator; methicillin-resistant; Staphylococcus aureus; MRSA; Streptomyces sp K04-0144; beta-lactam;

D O I：

10.1038/ja.2008.102

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyslabdan produced by Streptomyces sp. K04-0144 was found to potentiate imipenem activity against methicillin-resistant Staphylococcus aureus (MRSA). The MIC value of imipenem against MRSA was reduced from 16 to 0.0 15 mu g/ml in combination with cyslabdan. Study on anti-MRSA activity of other typical antibiotics in combination with cyslabdan showed that the potentiating activity was limited to beta-lactam antibiotics. Furthermore, among beta-lactam antibiotics, the activity of carbapenems was most remarkably poteintiated by cyslabdan.

引用

页码：7 / 10

页数：4

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