Sirtuins, Aging, and Medicine

被引：422

作者：

Guarente, Leonard ^{[1
,2
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] MIT, Paul F Glenn Lab, Cambridge, MA 02139 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 364卷 / 23期

关键词：

SMALL-MOLECULE ACTIVATORS; FATTY-ACID OXIDATION; CALORIE RESTRICTION; SIRT1; DEACETYLASE; GENE-EXPRESSION; LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; METABOLIC DISEASE; PROTECTS; LONGEVITY;

D O I：

10.1056/NEJMra1100831

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Populations in developed countries continue to grow older, as medical advances allow baby boomers to march inexorably onward. Many of the most important diseases that lead to disability and death occur late in life, indicating that aging itself is a key risk factor. Recent research into the science of aging has identified genes and pathways that appear to control the aging process. This review describes one such family of antiaging genes, the sirtuins, and details progress in understanding the biology that undergirds their promise as therapeutic targets.

引用

页码：2235 / 2244

页数：10

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