Sirtuins, Aging, and Medicine

被引：422

作者：

Guarente, Leonard ^{[1
,2
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] MIT, Paul F Glenn Lab, Cambridge, MA 02139 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2011年 / 364卷 / 23期

关键词：

SMALL-MOLECULE ACTIVATORS; FATTY-ACID OXIDATION; CALORIE RESTRICTION; SIRT1; DEACETYLASE; GENE-EXPRESSION; LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; METABOLIC DISEASE; PROTECTS; LONGEVITY;

D O I：

10.1056/NEJMra1100831

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Populations in developed countries continue to grow older, as medical advances allow baby boomers to march inexorably onward. Many of the most important diseases that lead to disability and death occur late in life, indicating that aging itself is a key risk factor. Recent research into the science of aging has identified genes and pathways that appear to control the aging process. This review describes one such family of antiaging genes, the sirtuins, and details progress in understanding the biology that undergirds their promise as therapeutic targets.

引用

页码：2235 / 2244

页数：10

共 90 条

[11] SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol [J].

Boily, G. ;

He, X. H. ;

Pearce, B. ;

Jardine, K. ;

McBurney, M. W. .

ONCOGENE, 2009, 28 (32) :2882-2893

[12] SIRT1 transgenic mice show phenotypes resembling calorie restriction [J].

Bordone, Laura ;

Cohen, Dena ;

Robinson, Ashley ;

Motta, Maria Carla ;

van Veen, Ed ;

Czopik, Agnieszka ;

Steele, Andrew D. ;

Crowe, Hayley ;

Marmor, Stephen ;

Luo, Jianyuan ;

Gu, Wei ;

Guarente, Leonard .

AGING CELL, 2007, 6 (06) :759-767

[13] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[14] AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity [J].

Canto, Carles ;

Gerhart-Hines, Zachary ;

Feige, Jerome N. ;

Lagouge, Marie ;

Noriega, Lilia ;

Milne, Jill C. ;

Elliott, Peter J. ;

Puigserver, Pere ;

Auwerx, Johan .

NATURE, 2009, 458 (7241) :1056-U140

[15] Tissue-specific regulation of SIRT1 by calorie restriction [J].

Chen, Danica ;

Bruno, Joanne ;

Easlon, Erin ;

Lin, Su-Ju ;

Cheng, Hwei-Ling ;

Alt, Frederick W. ;

Guarente, Leonard .

GENES & DEVELOPMENT, 2008, 22 (13) :1753-1757

[16] Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses [J].

Chen, WY ;

Wang, DH ;

Yen, RWC ;

Luo, JY ;

Gu, W ;

Baylin, SB .

CELL, 2005, 123 (03) :437-448

[17] SIRT1 Activation by Small Molecules KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR [J].

Dai, Han ;

Kustigian, Lauren ;

Carney, David ;

Case, April ;

Considine, Thomas ;

Hubbard, Basil P. ;

Perni, Robert B. ;

Riera, Thomas V. ;

Szczepankiewicz, Bruce ;

Vlasuk, George P. ;

Stein, Ross L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (43) :32695-32703

[18] SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10 (vol 142, pg 320, 2010) [J].

Donmez, Gizem ;

Wang, Diana ;

Cohen, Dena E. ;

Guarente, Leonard .

CELL, 2010, 142 (03) :494-495

[19] Aging and disease: connections to sirtuins [J].

Donmez, Gizem ;

Guarente, Leonard .

AGING CELL, 2010, 9 (02) :285-290

[20] Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice [J].

Escande, Carlos ;

Chini, Claudia C. S. ;

Nin, Veronica ;

Dykhouse, Katherine Minter ;

Novak, Colleen M. ;

Levine, James ;

van Deursen, Jan ;

Gores, Gregory J. ;

Chen, Junjie ;

Lou, Zhenkun ;

Chini, Eduardo Nunes .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) :545-558

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