Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

被引：94

作者：

Changeux, JP

Edelstein, SJ

机构：

[1] Inst Pasteur, Mol Neurobiol Lab, F-75724 Paris 15, France

[2] Univ Geneva, Dept Biochim, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(00)00221-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent chemical and advanced structural studies on site-directed and naturally occurring pathological mutants of individual members of the multigene family of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect 'allosteric' interactions between the acetylcholine-binding sites and the ion channel in signal transduction.

引用

收藏

页码：369 / 377

页数：9

相关论文

共 111 条

[1] INTERCELLULAR COMMUNICATION IN THE BRAIN - WIRING VERSUS VOLUME TRANSMISSION [J].

AGNATI, LF ;

ZOLI, M ;

STROMBERG, I ;

FUXE, K .

NEUROSCIENCE, 1995, 69 (03) :711-726

[2] Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision [J].

Akk, G ;

Steinbach, JH .

JOURNAL OF PHYSIOLOGY-LONDON, 2000, 527 (03) :405-417

[3] Mechanisms for activation and antagonism of an AMPA-Sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core [J].

Armstrong, N ;

Gouaux, E .

NEURON, 2000, 28 (01) :165-181

[4] Structure of a glutamate-receptor ligand-binding core in complex with kainate [J].

Armstrong, N ;

Sun, Y ;

Chen, GQ ;

Gouaux, E .

NATURE, 1998, 395 (6705) :913-917

[5]

Arroyo-Jiménez MD, 1999, J NEUROSCI, V19, P6475

[6] Neurobiology of the Caenorhabditis elegans genome [J].

Bargmann, CI .

SCIENCE, 1998, 282 (5396) :2028-2033

[7]

Bertrand D, 1999, Adv Neurol, V79, P171

[8] Paradoxical allosteric effects of competitive inhibitors on neuronal alpha 7 nicotinic receptor mutants [J].

Bertrand, S ;

DevillersThiery, A ;

Palma, E ;

Buisson, B ;

Edelstein, SJ ;

Corringer, PJ ;

Changeux, JP ;

Bertrand, D .

NEUROREPORT, 1997, 8 (16) :3591-3596

[9] Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the β2 subunit [J].

Bohler, S ;

Gay, S ;

Bertrand, S ;

Corringer, PJ ;

Edelstein, SJ ;

Changeux, JP ;

Bertrand, D .

BIOCHEMISTRY, 2001, 40 (07) :2066-2074

[10] Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors [J].

Brejc, K ;

van Dijk, WJ ;

Klaassen, RV ;

Schuurmans, M ;

van der Oost, J ;

Smit, AB ;

Sixma, TK .

NATURE, 2001, 411 (6835) :269-276

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