Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

被引：94

作者：

Changeux, JP

Edelstein, SJ

机构：

[1] Inst Pasteur, Mol Neurobiol Lab, F-75724 Paris 15, France

[2] Univ Geneva, Dept Biochim, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(00)00221-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent chemical and advanced structural studies on site-directed and naturally occurring pathological mutants of individual members of the multigene family of nicotinic acetylcholine receptors have yielded structure-function relationships supporting indirect 'allosteric' interactions between the acetylcholine-binding sites and the ion channel in signal transduction.

引用

收藏

页码：369 / 377

页数：9

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