Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19

被引：24

作者：

Belladonna, Maria Laura ^{[1
]}

Orabona, Ciriana ^{[1
]}

机构：

[1] Univ Perugia, Dept Expt Med, Perugia, Italy

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

COVID-19; tocilizumab; tryptophan catabolism; IDO1; cytokine storm syndrome; CORONAVIRUS;

D O I：

10.3389/fphar.2020.00959

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.

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