Aryl hydrocarbon receptor control of a disease tolerance defence pathway

被引：603

作者：

Bessede, Alban ^{[1
,2
]}

Gargaro, Marco ^{[1
]}

Pallotta, Maria T. ^{[1
]}

Matino, Davide ^{[1
]}

Servillo, Giuseppe ^{[1
]}

Brunacci, Cinzia ^{[1
]}

Bicciato, Silvio ^{[3
]}

Mazza, Emilia M. C. ^{[3
]}

Macchiarulo, Antonio ^{[4
]}

Vacca, Carmine ^{[1
]}

Iannitti, Rossana ^{[1
]}

Tissi, Luciana ^{[1
]}

Volpi, Claudia ^{[1
]}

Belladonna, Maria L. ^{[1
]}

Orabona, Ciriana ^{[1
]}

Bianchi, Roberta ^{[1
]}

Lanz, Tobias V. ^{[5
,6
]}

Platten, Michael ^{[5
,6
]}

Della Fazia, Maria A. ^{[1
]}

Piobbico, Danilo ^{[1
]}

Zelante, Teresa ^{[1
]}

Funakoshi, Hiroshi ^{[7
]}

Nakamura, Toshikazu ^{[8
]}

Gilot, David ^{[9
]}

Denison, Michael S. ^{[10
]}

Guillemin, Gilles J. ^{[11
]}

DuHadaway, James B. ^{[12
]}

Prendergast, George C. ^{[12
]}

Metz, Richard ^{[13
]}

Geffard, Michel ^{[2
]}

Boon, Louis ^{[14
]}

Pirro, Matteo ^{[15
]}

Iorio, Alfonso ^{[16
]}

Veyret, Bernard ^{[2
]}

Romani, Luigina ^{[1
]}

Grohmann, Ursula ^{[1
]}

Fallarino, Francesca ^{[1
]}

Puccetti, Paolo ^{[1
]}

机构：

[1] Univ Perugia, Dept Expt Med, I-06132 Perugia, Italy

[2] Univ Bordeaux, IMS Lab, F-33607 Pessac, France

[3] Univ Modena & Reggio Emilia, Ctr Genome Res, I-41125 Modena, Italy

[4] Univ Perugia, Dept Chem & Technol Drugs, I-06123 Perugia, Italy

[5] German Canc Res Ctr, Expt Neuroimmunol Unit, D-69120 Heidelberg, Germany

[6] Univ Hosp, Dept Neurooncol, D-69120 Heidelberg, Germany

[7] Asahikawa Med Univ, Ctr Adv Res & Educ, Asahikawa, Hokkaido 0788510, Japan

[8] Osaka Univ, Kringle Pharma Joint Res Div Regenerat Drug Disco, Ctr Adv Sci & Innovat, Suita, Osaka 5650871, Japan

[9] Univ Rennes 1, CNRS UMR6290, Inst Genet & Dev Rennes, F-35043 Rennes, France

[10] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA

[11] Macquarie Univ, ASAM, N Ryde, NSW 2109, Australia

[12] Lankenau Inst Med Res, Wynnewood, PA 19096 USA

[13] New Link Genetics Corp, Ames, IA 50010 USA

[14] Bioceros, NL-3584 Utrecht, Netherlands

[15] Univ Perugia, Dept Med, I-06132 Perugia, Italy

[16] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8S 4K1, Canada

来源：

NATURE | 2014年 / 511卷 / 7508期

关键词：

REGULATORY T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; TRYPTOPHAN CATABOLISM; DENDRITIC CELLS; ENDOTOXIN TOLERANCE; LIGAND-BINDING; AH RECEPTOR; KYNURENINE; IDO; INFECTION;

D O I：

10.1038/nature13323

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (endotoxin tolerance). We found that a first exposure of mice to LPS activated the ligand-operated transcription factor aryl hydrocarbon receptor (AhR) and the hepatic enzyme tryptophan 2,3-dioxygenase, which provided an activating ligand to the former, to down-regulate early inflammatory gene expression. However, on LPS rechallenge, AhR engaged in long-term regulation of systemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1). AhR-complex-associated Src kinase activity promoted IDO1 phosphorylation and signalling ability. There sulting endotoxin-tolerant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infections, pointing to a role for AhRin contributing to host fitness.

引用

页码：184 / +

页数：19

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[1]

Lipopolysaccharide-Activated Dendritic Cells: "Exhausted" or Alert and Waiting? [J].

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[4]

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Ligand binding and activation of the Ah receptor [J].

Denison, MS ;

Pandini, A ;

Nagy, SR ;

Baldwin, EP ;

Bonati, L .

CHEMICO-BIOLOGICAL INTERACTIONS, 2002, 141 (1-2) :3-24

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FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor [J].

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