IDO: more than an enzyme

被引：114

作者：

Chen, WanJun ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Mucosal Immunol Sect, NIH, Bethesda, MD USA

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 09期

关键词：

PLASMACYTOID DENDRITIC CELLS; TRYPTOPHAN CATABOLISM;

D O I：

10.1038/ni.2088

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-beta (TGF-beta), to induce a stably regulatory phenotype in plasmacytoid dendritic cells.

引用

页码：809 / U

页数：3

共 11 条

[1]

Cutting edge:: Autocrine TGF-β sustains default tolerogenesis by IDO-competent dendritic cells [J].

Belladonna, Maria L. ;

Volpi, Claudia ;

Bianchi, Roberta ;

Vacca, Camine ;

Orabona, Ciriana ;

Pallotta, Maria T. ;

Boon, Louis ;

Gizzi, Stefania ;

Fioretti, Maria C. ;

Grohmann, Ursula ;

Puccetti, Paolo .

JOURNAL OF IMMUNOLOGY, 2008, 181 (08) :5194-5198

[2]

TGF-β and kynurenines as the key to infectious tolerance [J].

Belladonna, Maria L. ;

Orabona, Ciriana ;

Grohmann, Ursula ;

Puccetti, Paolo .

TRENDS IN MOLECULAR MEDICINE, 2009, 15 (02) :41-49

[3]

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3 [J].

Chen, WJ ;

Jin, WW ;

Hardegen, N ;

Lei, KJ ;

Li, L ;

Marinos, N ;

McGrady, G ;

Wahl, SM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (12) :1875-1886

[4]

Plasmacytoid dendritic cells in immunity [J].

Colonna, M ;

Trinchieri, G ;

Liu, YJ .

NATURE IMMUNOLOGY, 2004, 5 (12) :1219-1226

[5]

CTLA-4-Ig regulates tryptophan catabolism in vivo [J].

Grohmann, U ;

Orabona, C ;

Fallarino, F ;

Vacca, C ;

Calcinaro, F ;

Falorni, A ;

Candeloro, P ;

Belladonna, ML ;

Bianchi, R ;

Fioretti, MC ;

Puccetti, P .

NATURE IMMUNOLOGY, 2002, 3 (11) :1097-1101

[6]

IDO expression by dendritic cells: Tolerance and tryptophan catabolism [J].

Mellor, AL ;

Munn, DH .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (10) :762-774

[7]

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling [J].

Neel, BG ;

Gu, HH ;

Pao, L .

TRENDS IN BIOCHEMICAL SCIENCES, 2003, 28 (06) :284-293

[8]

CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86 [J].

Orabona, C ;

Grohmann, U ;

Belladonna, ML ;

Fallarino, F ;

Vacca, C ;

Bianchi, R ;

Bozza, S ;

Volpi, C ;

Salomon, BT ;

Fioretti, MC ;

Romani, L ;

Puccetti, P .

NATURE IMMUNOLOGY, 2004, 5 (11) :1134-1142

[9]

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells [J].

Pallotta, Maria T. ;

Orabona, Ciriana ;

Volpi, Claudia ;

Vacca, Carmine ;

Belladonna, Maria L. ;

Bianchi, Roberta ;

Servillo, Giuseppe ;

Brunacci, Cinzia ;

Calvitti, Mario ;

Bicciato, Silvio ;

Mazza, Emilia M. C. ;

Boon, Louis ;

Grassi, Fabio ;

Fioretti, Maria C. ;

Fallarino, Francesca ;

Puccetti, Paolo ;

Grohmann, Ursula .

NATURE IMMUNOLOGY, 2011, 12 (09) :870-U91

[10]

Plasmacytoid Dendritic Cells: Recent Progress and Open Questions [J].

Reizis, Boris ;

Bunin, Anna ;

Ghosh, Hiyaa S. ;

Lewis, Kanako L. ;

Sisirak, Vanja .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :163-183

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