IDO expression by dendritic cells: Tolerance and tryptophan catabolism

被引：1889

作者：

Mellor, AL ^{[1
]}

Munn, DH

机构：

[1] Med Coll Georgia, Dept Med, Inst Mol Med & Genet, Program Mol Immunol, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Pediat, Inst Mol Med & Genet, Program Mol Immunol, Augusta, GA 30912 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1457

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Indoleamine 2,3-dioxygenase (IDO) is an enzyme that degrades the essential amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell responses and promote tolerance is a relatively new paradigm in immunology. Considerable evidence now supports this hypothesis, including studies of mammalian pregnancy, tumour resistance, chronic infections and autoimmune diseases. In this review, we summarize key recent developments and propose a unifying model for the role of IDO in tolerance induction.

引用

页码：762 / 774

页数：13

共 153 条

[1]

Role of indoleamine-2,3-dioxygenase in alpha/beta and gamma interferon-mediated antiviral effects against herpes simplex virus infections [J].

Adams, O ;

Besken, K ;

Oberdörfer, C ;

MacKenzie, CR ;

Takikawa, O ;

Däubener, W .

JOURNAL OF VIROLOGY, 2004, 78 (05) :2632-2636

[2]

Determination of the nature of the heme environment in nitrosyl indoleamine 2,3-dioxygenase using multiple-scattering analyses of X-ray absorption fine structure [J].

Aitken, JB ;

Thomas, SE ;

Stocker, R ;

Thomas, SR ;

Takikawa, O ;

Armstrong, RS ;

Lay, PA .

BIOCHEMISTRY, 2004, 43 (17) :4892-4898

[3]

Indoleamine 2,3-dioxygenase expression in trans-planted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes [J].

Alexander, AM ;

Crawford, M ;

Bertera, S ;

Rudert, WA ;

Takikawa, O ;

Robbins, PD ;

Trucco, M .

DIABETES, 2002, 51 (02) :356-365

[4]

'Educated' dendritic cells act as messengers from memory to naive T helper cells [J].

Alpan, O ;

Bachelder, E ;

Isil, E ;

Arnheiter, H ;

Matzinger, P .

NATURE IMMUNOLOGY, 2004, 5 (06) :615-622

[5]

Regulatory T cells mediate maternal tolerance to the fetus [J].

Aluvihare, VR ;

Kallikourdis, M ;

Betz, AG .

NATURE IMMUNOLOGY, 2004, 5 (03) :266-271

[6]

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific [J].

Baban, B ;

Chandler, P ;

McCool, D ;

Marshall, B ;

Munn, DH ;

Mellor, AL .

JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2004, 61 (02) :67-77

[7]

Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor α in interferon-treated epithelial cells [J].

Babcock, TA ;

Carlin, JM .

CYTOKINE, 2000, 12 (06) :588-594

[8]

Barceló-Batllori S, 2002, PROTEOMICS, V2, P551, DOI 10.1002/1615-9861(200205)2:5<551::AID-PROT551>3.0.CO

[9]

2-O

[10]

Adjuvants of immunity: Harnessing innate immunity to promote adaptive immunity [J].

Bendelac, A ;

Medzhitov, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :F19-F23

← 1 2 3 4 5 6 7 8 9 10 →