Do maternally acquired antibodies protect infants from malaria infection?

被引：99

作者：

Riley, EM

Wagner, GE

Akanmori, BD

Koram, KA

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

[2] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh, Midlothian, Scotland

[3] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Ghana

来源：

PARASITE IMMUNOLOGY | 2001年 / 23卷 / 02期

关键词：

malaria; materno-foetal antibody transfer; neonate; infant;

D O I：

10.1046/j.1365-3024.2001.00364.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neonates and infants are relatively protected from clinical malaria. hut the mechanism of this protection is not well understood Maternally derived antibodies are commonly believed to provide protection against many infectious diseases, including malaria, for periods of up to 6-9 months but several recent epidemiological studies have produced conflicting results regarding a protective role of passively acquired antimalarial antibodies, In this article, we review the epidemiological evidence for resistance of young infants to malaria, summarize the data on anti-malarial antibody levels and specificity and their association with protection from malaria infection or clinical disease, and explore alternative explanations for resistance to malaria in infants.

引用

页码：51 / 59

页数：9

共 67 条

[11] PLASMODIUM-FALCIPARUM MALARIA - EVIDENCE FOR AN ISOTYPE IMBALANCE WHICH MAY BE RESPONSIBLE FOR DELAYED ACQUISITION OF PROTECTIVE IMMUNITY [J].