Stereoselective synthesis of a functionalized 2-oxo-1-azabicyclo[5.3.0]alkane as a potential scaffold for targeted chemotherapy strategies

被引：15

作者：

Bracci, A

Manzoni, L

Scolastico, C

机构：

[1] ISTM, I-20133 Milan, Italy

[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[3] Univ Milan, CISI, I-20133 Milan, Italy

来源：

SYNTHESIS-STUTTGART | 2003年 / 15期

关键词：

metathesis; ring closure; lactams; bicyclic compounds; asymmetric synthesis; peptides;

D O I：

10.1055/s-2003-42400

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of functionalized 2-oxo-1-azabicyclo[5.3.0]alkane is presented. Key events of the synthetic sequence were the stereoselective propenylation of an N-acyliminium ion and a ring-closing metathesis reaction forming a 7-membered lactam.

引用

收藏

页码：2363 / 2367

页数：5

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