Synthesis of indolizidines (-)-195B, (-)-223AB and (-)-239AB:: (2S,5R)-1-[(benzyloxy)carbonyl]-2-methoxycarbonyl-5-(4-pentenyl)pyrrolidine as a versatile chiral building block

被引：32

作者：

Célimène, C ^{[1
]}

Dhimane, H ^{[1
]}

Lhommet, G ^{[1
]}

机构：

[1] Univ Pierre & Marie Curie, Lab Chim Heterocycles, UMR 7611, F-75252 Paris, France

来源：

TETRAHEDRON | 1998年 / 54卷 / 35期

关键词：

D O I：

10.1016/S0040-4020(98)00498-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total syntheses of three levogyre 3,5-disubstituted indolizidines, (-) 195B, (-)-223AB and (-)-239AB are described. The employed strategy is based on the utilization of the common enantiopure trans 2,5-disubstituted pyrrolidine 3, which is assembled by addition of pent-4-enylcopper to N-acyl iminium ion derived from (S)-proline. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：10457 / 10468

页数：12

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