The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells

被引：6

作者：

Jang, Hye-Ock ^{[1
,2
]}

Kim, Ji-Suk ^{[3
]}

Kwon, Woo-Cheol ^{[4
,5
]}

Kim, Jeong-Kuk ^{[1
,2
]}

Ko, Myung-Suk ^{[1
,2
]}

Kim, Dong-Hoo ^{[1
,2
]}

Kim, Won-Il ^{[1
,2
]}

Jeon, Young-Chan ^{[6
]}

Chung, In-Kyo ^{[4
,5
]}

Shin, Sang-Hun ^{[4
,5
]}

Chung, Jin ^{[3
]}

Bae, Moon-Kyung ^{[7
]}

Yun, Il ^{[1
,2
]}

机构：

[1] Pusan Natl Univ, Dept Dent Pharmacol & Biophys, Coll Dent, Pusan 602739, South Korea

[2] Pusan Natl Univ, Res Inst Oral Biotechnol, Pusan 602739, South Korea

[3] Pusan Natl Univ, Dept Microbiol, Coll Dent, Pusan 602739, South Korea

[4] Pusan Natl Univ, Dept Oral & Maxillofacial Surg, Coll Dent, Pusan 602739, South Korea

[5] Pusan Natl Univ, Dept Clin Pharmacol, Coll Dent, Pusan 602739, South Korea

[6] Pusan Natl Univ, Dept Prosthodont, Coll Dent, Pusan 602739, South Korea

[7] Pusan Natl Univ, Dept Oral Physiol & Mol Biol, Coll Dent, Pusan 602739, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 02期

关键词：

lead; calcium influx; osteoblast-like cells; fluorescence probe technique;

D O I：

10.1007/s12272-001-1140-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). Pb2+ inhibited the immediate CRACI dose-dependent manner. Influx of Pb2+ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of Pb2+ with CRACI of human OLC is at least twofold: (1) the initiation of CRACI, i.e., the measurable influx of Ca2+ upon Ca2+ readdition, is partially inhibited by Pb2+ and (2) the influx of Pb2+, was enhanced after CRACI had been induced.

引用

页码：188 / 194

页数：7

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