Comparative Genomics of Cell Envelope Components in Mycobacteria

被引：15

作者：

Banerjee, Ruma ^{[1
]}

Vats, Pankaj ^{[1
]}

Dahale, Sonal ^{[1
]}

Kasibhatla, Sunitha Manjari ^{[1
]}

Joshi, Rajendra ^{[1
]}

机构：

[1] Ctr Dev Adv Comp, Bioinformat Grp, Pune, Maharashtra, India

来源：

PLOS ONE | 2011年 / 6卷 / 05期

关键词：

MYCOLIC ACIDS; PHTHIOCEROL DIMYCOCEROSATE; METABOLIC PATHWAYS; CRYSTAL-STRUCTURE; GENE DECAY; TUBERCULOSIS; LIPOARABINOMANNAN; IDENTIFICATION; SEQUENCE; WALL;

D O I：

10.1371/journal.pone.0019280

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mycobacterial cell envelope components have been a major focus of research due to their unique features that confer intrinsic resistance to antibiotics and chemicals apart from serving as a low-permeability barrier. The complex lipids secreted by Mycobacteria are known to evoke/repress host-immune response and thus contribute to its pathogenicity. This study focuses on the comparative genomics of the biosynthetic machinery of cell wall components across 21-mycobacterial genomes available in GenBank release 179.0. An insight into survival in varied environments could be attributed to its variation in the biosynthetic machinery. Gene-specific motifs like 'DLLAQPTPAW' of ufaA1 gene, novel functional linkages such as involvement of Rv0227c in mycolate biosynthesis; Rv2613c in LAM biosynthesis and Rv1209 in arabinogalactan peptidoglycan biosynthesis were detected in this study. These predictions correlate well with the available mutant and coexpression data from TBDB. It also helped to arrive at a minimal functional gene set for these biosynthetic pathways that complements findings using TraSH.

引用

页数：13

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