"Go With the Flow": How Kruppel-Like Factor 2 Regulates the Vasoprotective Effects of Shear Stress

被引：101

作者：

Nayak, Lalitha ^{[1
]}

Lin, Zhiyong ^{[2
]}

Jain, Mukesh K. ^{[2
]}

机构：

[1] Case Western Reserve Univ, Div Hematol Oncol, Dept Med, Sch Med,Univ Hosp, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Sch Med, Dept Med,Univ Hosp Case Med Ctr, Case Cardiovasc Res Inst,Univ Hosp Harrington McL, Cleveland, OH 44106 USA

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 15卷 / 05期

关键词：

KLF2 TRANSCRIPTION FACTOR; ZINC-FINGER PROTEIN; CELL DIFFERENTIATION MARKERS; DEPENDENT NUCLEAR EXPORT; VEIN ENDOTHELIAL-CELLS; NITRIC-OXIDE SYNTHASE; EMBRYONIC STEM-CELLS; GENE-EXPRESSION; SMOOTH-MUSCLE; IN-VIVO;

D O I：

10.1089/ars.2010.3647

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Laminar shear stress is known to confer potent anti-inflammatory, antithrombotic, and antiadhesive effects by differentially regulating endothelial gene expression. The identification of Kruppel-like factor 2 as a flow-responsive molecule has greatly advanced our understanding of molecular mechanisms governing vascular homeostasis. This review summarizes the current understanding of Kruppel-like factor 2 action in endothelial gene expression and function. Antioxid. Redox Signal. 15, 1449-1461.

引用

页码：1449 / 1461

页数：13

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