Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice

被引:47
作者
Ahn, Eun Hee [1 ,2 ]
Kim, Dae Won [1 ,2 ]
Kang, Hye Won [1 ,2 ]
Shin, Min Jae [1 ,2 ]
Won, Moo Ho [3 ]
Kim, Joon [4 ]
Kim, Dong Joon [5 ]
Kwon, Oh-Shin [6 ]
Kang, Tae-Cheon [3 ]
Han, Kyu Hyung [1 ,2 ]
Park, Jinseu [1 ,2 ]
Eum, Won Sik [1 ,2 ]
Choi, Soo Young [1 ,2 ]
机构
[1] Hallym Univ, Dept Biomed Sci, Chunchon 200702, South Korea
[2] Hallym Univ, Res Inst Biosci & Biotechnol, Chunchon 200702, South Korea
[3] Hallym Univ, Coll Med, Dept Anat & Neurobiol, Chunchon 200702, South Korea
[4] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136701, South Korea
[5] Hallym Univ, Chuncheon Sacred Heart Hosp, Dept Internal Med, Chunchon 200702, South Korea
[6] Kyungpook Natl Univ, Dept Biochem, Taegu 702701, South Korea
关键词
Inflammation; MAPK; PEP-1-rpS3; TPA; NF-KAPPA-B; SKIN INFLAMMATION; NITRIC-OXIDE; EFFICIENTLY PROTECTS; RIBOSOMAL-PROTEIN; ISCHEMIC INSULT; L-ARGININE; IN-VIVO; PATHWAYS; CARCINOGENESIS;
D O I
10.1016/j.tox.2010.08.004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
This study investigated the preventive effect of ribosomal protein S3 (rpS3) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. A cell permeable expression vector PEP-1-rpS3 was constructed. Topical application of the vector markedly inhibited TPA-induced expression levels of cyclooxygenase-2 (COX-2) and pro-inflammatory cytokines. Application of PEP-1-rpS3 also resulted in a significant reduction in the activation of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) in TPA-treated ears. These results indicate that PEP-1-rpS3 inhibits inflammatory response cytokines and enzymes by blocking NF-kappa B and MAPK, prompting the suggestion that PEP-1-rpS3 can be used as a therapeutic agent against skin inflammation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:192 / 197
页数:6
相关论文
共 37 条
[1]   Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult [J].
An, Jae J. ;
Lee, Yeom P. ;
Kim, So Y. ;
Lee, Sun H. ;
Lee, Min J. ;
Jeong, Min S. ;
Kim, Dae W. ;
Jang, Sang H. ;
Yoo, Ki-Yeon ;
Won, Moo H. ;
Kang, Tae-Cheon ;
Kwon, Oh-Shin ;
Cho, Sung-Woo ;
Lee, Kil S. ;
Park, Jinseu ;
Eum, Won S. ;
Choi, Soo Y. .
FEBS JOURNAL, 2008, 275 (06) :1296-1308
[2]   Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: Critical remarks [J].
Bertolini, A ;
Ottani, A ;
Sandrini, M .
CURRENT MEDICINAL CHEMISTRY, 2002, 9 (10) :1033-1043
[3]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[4]   Cyclooxygenase enzymes in allergic inflammation and asthma [J].
Carey, MA ;
Germolec, DR ;
Langenbach, R ;
Zeldin, DC .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2003, 69 (2-3) :157-162
[5]   Human PEP-1-ribosomal protein S3 protects against UV-induced skin cell death [J].
Choi, Soo Hyun ;
Kim, So Young ;
An, Jae Jin ;
Lee, Sun Hwa ;
Kim, Dae Won ;
Ryu, Hea Jin ;
Lee, Nam Il ;
Yeo, Seung Il ;
Jang, Sang Ho ;
Won, Moo Ho ;
Kang, Tae-Cheon ;
Kwon, Hyung Joo ;
Cho, Sung-Woo ;
Kim, Joon ;
Lee, Kil Soo ;
Park, Jinseu ;
Eum, Won Sik ;
Choi, Soo Young .
FEBS LETTERS, 2006, 580 (30) :6755-6762
[6]   Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-κB [J].
Chung, Won Yoon ;
Park, Jae Hee ;
Kim, Mi Jeong ;
Kim, Heui Ok ;
Hwang, Jae Kwan ;
Lee, Sang Kook ;
Park, Kwang Kyun .
CARCINOGENESIS, 2007, 28 (06) :1224-1231
[7]   Topical application of a novel immunomodulatory peptide, RDP58, reduces skin inflammation in the phorbol ester-induced dermatitis model [J].
De Vry, CG ;
Valdez, M ;
Lazarov, M ;
Muhr, E ;
Buelow, R ;
Fong, T ;
Iyer, S .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (03) :473-481
[8]   The role of AP-1, NF-κB and ROS/NOS in skin carcinogenesis:: The JB6 model is predictive [J].
Dhar, A ;
Young, MR ;
Colburn, NH .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2002, 234 (01) :185-193
[9]   In vivo protein transduction: Biologically active intact PEP-1-superoxide dismutase fusion protein efficiently protects against ischemic insult [J].
Eum, WS ;
Kim, DW ;
Hwang, IK ;
Yoo, KY ;
Kang, TC ;
Jang, SH ;
Choi, HS ;
Choi, SH ;
Kim, YH ;
Kim, SY ;
Kwon, HY ;
Kang, JH ;
Kwon, OS ;
Cho, SW ;
Lee, KS ;
Park, R ;
Won, MH ;
Choi, SY .
FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (10) :1656-1669
[10]   Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFα, IL-1β, NO and MAP kinases [J].
Gayathri, B. ;
Manjula, N. ;
Vinaykumar, K. S. ;
Lakshmi, B. S. ;
Balakrishnan, A. .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2007, 7 (04) :473-482