Enhanced diffusion in active intracellular transport

被引：390

作者：

Caspi, A ^{[1
]}

Granek, R ^{[1
]}

Elbaum, M ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mat & Interfaces, IL-76100 Rehovot, Israel

来源：

PHYSICAL REVIEW LETTERS | 2000年 / 85卷 / 26期

关键词：

D O I：

10.1103/PhysRevLett.85.5655

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We show that within a living eukaryotic cell, mean square displacement of an engulfed microsphere shows enhanced diffusion scaling as t(3/2) at short times, with a clear crossover to subdiffusive or ordinary diffusion scaling at longer times. The motion, observed nearby the nucleus, is due to interactions with microtubule-associated motor proteins rather than thermal Brownian motion. We propose that time-dependent friction introduced by the intracellular polymer networks leads to sub-ballistic motion, analogous to subdiffusion observed in passive networks of semiflexible biopolymers.

引用

页码：5655 / 5658

页数：4

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