Synthesis and evaluation of chromogenic and fluorogenic analogs of glycerol for enzyme assays

被引：30

作者：

González-García, EM ^{[1
]}

Grognux, J ^{[1
]}

Wahler, D ^{[1
]}

Reymond, JL ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

来源：

HELVETICA CHIMICA ACTA | 2003年 / 86卷 / 07期

关键词：

D O I：

10.1002/hlca.200390199

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The branched glycerol analogs 1 and 2 were prepared. Mono-ester derivatives of these triols undergo a chromogenic or fluorogenic reaction in the presence of NaIO4. In contrast, both the diesters and the triols are themselves not chromogenic or fluorogenic. Diester derivatives of these triols can be used as probes for lipases. The tris-phosphate derivative of I is a fluorogenic substrate for various phosphatases.

引用

页码：2458 / 2470

页数：13

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