Metformin Treatment Alters Memory Function in a Mouse Model of Alzheimer's Disease

被引：90

作者：

DiTacchio, Kacee A. ^{[1
]}

Heinemann, Stephen F. ^{[1
]}

Dziewczapolski, Gustavo ^{[1
]}

机构：

[1] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2015年 / 44卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; AMPK; metformin; type 2 diabetes mellitus; LIFE-SPAN; MICE; RISK; EXERCISE; DEFICITS; LIVER; DEMENTIA; AMPK;

D O I：

10.3233/JAD-141332

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD.

引用

页码：43 / 48

页数：6

共 25 条

[1]

Metformin slows down aging and extends life span of female SHR mice [J].

Anisimov, Vladimir N. ;

Berstein, Lev M. ;

Egormin, Peter A. ;

Piskunova, Tatiana S. ;

Popovich, Irina G. ;

Zabezhinski, Mark A. ;

Tyndyk, Margarita L. ;

Yurova, Maria V. ;

Kovalenko, Irina G. ;

Poroshina, Tatiana E. ;

Semenchenko, Anna V. .

CELL CYCLE, 2008, 7 (17) :2769-2773

[2]

Metformin for aging and cancer prevention [J].

Anisimov, Vladimir N. .

AGING-US, 2010, 2 (11) :760-774

[3]

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice [J].

Anisimov, VN ;

Berstein, LM ;

Egormin, PA ;

Piskunova, TS ;

Popovich, IG ;

Zabezhinski, MA ;

Kovalenko, IG ;

Poroshina, TE ;

Semenchenko, AV ;

Provinciali, M ;

Re, F ;

Franceschi, C .

EXPERIMENTAL GERONTOLOGY, 2005, 40 (8-9) :685-693

[4]

Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease [J].

Cao, Dongfeng ;

Lu, Hailin ;

Lewis, Terry L. ;

Li, Ling .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (50) :36275-36282

[5]

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription [J].

Chen, Yaomin ;

Zhou, Kun ;

Wang, Ruishan ;

Liu, Yun ;

Kwak, Young-Don ;

Ma, Tao ;

Thompson, Robert C. ;

Zhao, Yongbo ;

Smith, Layton ;

Gasparini, Laura ;

Luo, Zhijun ;

Xu, Huaxi ;

Liao, Francesca-Fang .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3907-3912

[6]

Deletion of the α7 Nicotinic Acetylcholine Receptor Gene Improves Cognitive Deficits and Synaptic Pathology in a Mouse Model of Alzheimer's Disease [J].

Dziewczapolski, Gustavo ;

Glogowski, Carolina M. ;

Masliah, Eliezer ;

Heinemann, Stephen F. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (27) :8805-8815

[7]

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells [J].

Greco, Steven J. ;

Sarkar, Sraboni ;

Johnston, Jane M. ;

Tezapsidis, Nikolaos .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 380 (01) :98-104

[8]

Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes [J].

Gupta, Amit ;

Bisht, Bharti ;

Dey, Chinmoy Sankar .

NEUROPHARMACOLOGY, 2011, 60 (06) :910-920

[9]

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease [J].

Halagappa, Veerendra Kumar Madald ;

Guo, Zhihong ;

Pearson, Michelle ;

Matsuoka, Yasuji ;

Cutler, Roy G. ;

LaFerla, Frank M. ;

Mattson, Mark P. .

NEUROBIOLOGY OF DISEASE, 2007, 26 (01) :212-220

[10]

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models [J].

Hsia, AY ;

Masliah, E ;

McConlogue, L ;

Yu, GQ ;

Tatsuno, G ;

Hu, K ;

Kholodenko, D ;

Malenka, RC ;

Nicoll, RA ;

Mucke, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3228-3233

← 1 2 3 →