Mucosal irritation potential of polyelectrolyte multilayer capsules

被引：25

作者：

De Cock, Liesbeth J. ^{[1
]}

Lenoir, Joke ^{[1
]}

De Koker, Stefaan ^{[2
]}

Vermeersch, Vincent ^{[3
]}

Skirtach, Andrei G. ^{[4
]}

Dubruel, Peter ^{[3
]}

Adriaens, Els ^{[1
]}

Vervaet, Chris ^{[1
]}

Remon, Jean Paul ^{[1
]}

De Geest, Bruno G. ^{[1
]}

机构：

[1] Univ Ghent, Dept Pharmaceut, Pharmaceut Technol Lab, B-9000 Ghent, Belgium

[2] Univ Ghent, Dept Mol Biomed Res, B-9052 Zwijnaarde, Belgium

[3] Univ Ghent, Polymer Chem & Biomat Res Grp, B-9000 Ghent, Belgium

[4] Max Planck Inst Colloids & Interfaces, Golm, Germany

来源：

BIOMATERIALS | 2011年 / 32卷 / 07期

关键词：

Mucosa; Microcapsule; Drug delivery; Heparin; Biocompatibility; MACROMOLECULE ENCAPSULATION; PROTEIN ENCAPSULATION; CROSS-PRESENTATION; DENDRITIC CELLS; MICROCAPSULES; DELIVERY; TOXICITY; RELEASE; TOOL;

D O I：

10.1016/j.biomaterials.2010.11.012

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polyelectrolyte multilayer capsules have recently gained interest as carriers for drug delivery. When envisioning mucosal administration, one is focused with potential concerns such as tissue irritation and tissue damage, induced by the carrier itself. In this paper we demonstrate the use of a slug-based (Anon lusitanicus) assay to evaluate the mucosal irritation potential of different types of polyelectrolytes, their complexes and multilayer capsules. This assay allows to assess in a simple yet efficient way mucosal tissue irritation without using large numbers of vertebrates such as mice, rabbits or non-human primates. We found that although single polyelectrolyte components do induce tissue irritation, this response is dramatically reduced upon complexation with an oppositely charged polyelectrolyte, rendering fairly inert polyelectrolyte complexes. These findings put polyelectrolyte multilayer capsules further en route towards drug delivery applications. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1967 / 1977

页数：11

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