Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection

被引:111
作者
Sprenger, H
Meyer, RG
Kaufmann, A
Bussfeld, D
Rischkowsky, E
Gemsa, D
机构
[1] Institute of Immunology, Philipps-University Marburg
[2] Institute of Immunology, Philipps-University Marburg, D-35037 Marburg
关键词
D O I
10.1084/jem.184.3.1191
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It is characteristic for virus infections that monocytes/macrophages and lymphocytes infiltrate infected tissue while neutrophils are absent. To understand the mechanisms selectively attracting mononuclear cells in viral diseases, we examined in an influenza A virus model the expression and regulation of chemokines as candidate molecules responsible for the immigration of leukocytes into inflamed tissue. After influenza A virus infection of human monocytes, a rapid expression of the mononuclear cell attracting CC-chemokine genes MIP-1, MCP-1, and RANTES occulted which was followed by the release of chemokine proteins. In striking contrast to CC-chemokines, the expression of the prototype neutrophil CXC-chemoattractants IL-8 and GR O-alpha was completely suppressed after influenza A infection. The release of other neutrophil chemotactic factors was excluded by microchemotaxis assays. These results suggest that the virus-specific induction of mononuclear cell-attracting chemokines accounts for the preferential influx of mononuclear leukocytes into virus-infected tissue.
引用
收藏
页码:1191 / 1196
页数:6
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