The synthesis of GoldMag nano-particles and their application for antibody immobilization

被引：124

作者：

Cui, YL ^{[1
]}

Wang, YN

Hui, WL

Zhang, ZF

Xin, XF

Chen, C

机构：

[1] NW Univ Xian, Biochip Res & Dev Ctr, Xian 710069, Peoples R China

[2] Natl Engn Res Ctr Miniaturized Detect Syst, Xian 710069, Peoples R China

[3] Shaanxi Lifegen Ltd Xian, Xian 710002, Shaanxi, Peoples R China

来源：

BIOMEDICAL MICRODEVICES | 2005年 / 7卷 / 02期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Fe3O4/Au; nanopaticle; antibody; immobilization;

D O I：

10.1007/s10544-005-1596-x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 [生物医学工程];

摘要：

Fe3O4/Au (GoldMag) particles with core/shell structure were synthesized by reduction of Au3+ with hydroxylamine in the presence of Fe3O4. The synthesized particles have an average size smaller than 100 nm in diameter with of superparemagnetic properties due to their Fe oxide cores. The particles show optical features with a plasmon resonance peak from 550, 570 to 590 nm correlating with increasing diameters from 50 nm, 70 nm to 100 nm.The GoldMag particles need only a single step for antibody immobilization and have high binding capacity for antibodies. These advantages permit improved methods of isolating and detecting biomolecules.

引用

页码：153 / 156

页数：4

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