Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy

被引:616
作者
Krishnan, Kannan M. [1 ]
机构
[1] Univ Washington, Dept Mat Sci, Seattle, WA 98195 USA
关键词
Biomedical engineering; diagnostics; imaging; magnetic relaxation; nanotechnology; small particles; superparamagnetism; therapy; SUPERPARAMAGNETIC IRON-OXIDE; RAPID COLORIMETRIC ASSAY; HEAT-SHOCK PROTEINS; MAGNETIC NANOPARTICLES; CONTRAST AGENTS; DRUG-DELIVERY; COBALT NANOCRYSTALS; ANTITUMOR IMMUNITY; CIRCULATION TIME; PARTICLE-SIZE;
D O I
10.1109/TMAG.2010.2046907
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Biomedical nanomagnetics is a multidisciplinary area of research in science, engineering and medicine with broad applications in imaging, diagnostics and therapy. Recent developments offer exciting possibilities in personalized medicine provided a truly integrated approach, combining chemistry, materials science, physics, engineering, biology and medicine, is implemented. Emphasizing this perspective, here we address important issues for the rapid development of the field, i.e., magnetic behavior at the nanoscale with emphasis on the relaxation dynamics, synthesis and surface functionalization of nanoparticles and core-shell structures, biocompatibility and toxicity studies, biological constraints and opportunities, and in vivo and in vitro applications. Specifically, we discuss targeted drug delivery and triggered release, novel contrast agents for magnetic resonance imaging, cancer therapy using magnetic fluid hyperthermia, in vitro diagnostics and the emerging magnetic particle imaging technique, that is quantitative and sensitive enough to compete with established imaging methods. In addition, the physics of self-assembly, which is fundamental to both biology and the future development of nanoscience, is illustrated with magnetic nanoparticles. It is shown that various competing energies associated with self-assembly converge on the nanometer length scale and different assemblies can be tailored by varying particle size and size distribution. Throughout this paper, while we discuss our recent research in the broad context of the multidisciplinary literature, we hope to bridge the gap between related work in physics/chemistry/engineering and biology/medicine and, at the same time, present the essential concepts in the individual disciplines. This approach is essential as biomedical nanomagnetics moves into the next phase of innovative translational research with emphasis on development of quantitative in vivo imaging, targeted and triggered drug release, and image guided therapy including validation of delivery and therapy response.
引用
收藏
页码:2523 / 2558
页数:36
相关论文
共 271 条
[61]   Optimization of nanoparticle core size for magnetic particle imaging [J].
Ferguson, R. Matthew ;
Minard, Kevin R. ;
Krishnan, Kannan M. .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2009, 321 (10) :1548-1551
[62]  
FERGUSON RM, P INT WORKS IN PRESS
[63]  
FERIDE C, 2006, J PHARMACOL EXP THER, V318, P108
[64]   Cancer nanotechnology: Opportunities and challenges [J].
Ferrari, M .
NATURE REVIEWS CANCER, 2005, 5 (03) :161-171
[65]   CRITICAL SIZE AND NUCLEATION FIELD OF IDEAL FERROMAGNETIC PARTICLES [J].
FREI, EH ;
SHTRIKMAN, S ;
TREVES, D .
PHYSICAL REVIEW, 1957, 106 (03) :446-454
[66]   DETAILED TOXICITY STUDIES OF LIPOSOMAL GADOLINIUM-DTPA [J].
FRITZ, T ;
UNGER, E ;
WILSONSANDERS, S ;
AHKONG, QF ;
TILCOCK, C .
INVESTIGATIVE RADIOLOGY, 1991, 26 (11) :960-968
[67]  
FUJII T, 2005, MICROSC MICROANAL, V11, P810
[68]   Spiral spin order of self-assembled Co nanodisk arrays [J].
Gao, Y ;
Bao, YP ;
Pakhomov, AB ;
Shindo, D ;
Krishnan, KM .
PHYSICAL REVIEW LETTERS, 2006, 96 (13)
[69]   Superstructures of self-assembled cobalt nanocrystals [J].
Gao, YH ;
Bao, YP ;
Beerman, M ;
Yasuhara, A ;
Shindo, D ;
Krishnan, KM .
APPLIED PHYSICS LETTERS, 2004, 84 (17) :3361-3363
[70]   Classification and basic properties of contrast agents for magnetic resonance imaging [J].
Geraldes, Carlos F. G. C. ;
Laurent, Sophie .
CONTRAST MEDIA & MOLECULAR IMAGING, 2009, 4 (01) :1-23