Azulenyl nitrone spin traps protect against MPTP neurotoxicity

被引：23

作者：

Klivenyi, P ^{[1
]}

Matthews, RT

Wermer, M

Yang, LC

MacGarvey, U

Becker, DA

Natero, R

Beal, MF

机构：

[1] Massachusetts Gen Hosp, Neurol Serv, Neurochem Lab, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] Florida Int Univ, Dept Chem, Miami, FL 33199 USA

来源：

EXPERIMENTAL NEUROLOGY | 1998年 / 152卷 / 01期

关键词：

MPTP; Parkinson's disease; free radicals; oxidative damage; spin traps; antioxidants;

D O I：

10.1006/exnr.1998.6824

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Azulenyl nitrones are a unique class of free radical spin-trapping compounds. We administered both a water-soluble and a lipid-soluble azulenyl nitrone to mice prior to administration of MPTP. Both compounds produced significant neuroprotection against depletions of dopamine and its metabolites measured 1 week. after MPTP administration. There were no effects on MPP+ levels. These findings provide further evidence that free radical scavengers can produce significant neuroprotection against MPTP neurotoxicity (C) 1998 Academic Press.

引用

页码：163 / 166

页数：4

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