A direct and efficient stereoconservative procedure for the selective oxidation of N-protected β-amino alcohols

被引：27

作者：

Ocejo, M ^{[1
]}

Vicario, JL ^{[1
]}

Badía, D ^{[1
]}

Carrillo, L ^{[1
]}

Reyes, E ^{[1
]}

机构：

[1] Univ Basque Country, Fac Ciencias & Tecnol, Dept Quim Organ 2, E-48080 Bilbao, Spain

来源：

SYNLETT | 2005年 / 13期

关键词：

amino aldehydes; amino alcohols; oxidations; iodine; green chemistry;

D O I：

10.1055/s-2005-871947

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, very simple and eco-friendly procedure has been developed for the synthesis of highly enantioenriched alpha-amino aldehydes by IBX-mediated oxidation of the corresponding beta-amino alcohols. The procedure has been applied to a wide range of substrates with different side chains and protecting groups showing that the final aldehydes can be obtained in very high yields and with no racemization at the stereogenic center present in the starting compounds.

引用

页码：2110 / 2112

页数：3

共 53 条

[1] 4-Oxoazetidine-2-carbaldehydes as useful building blocks in stereocontrolled synthesis [J].