Sequence typing confirms that Campylobacter jejuni strains associated with Guillain-Barre and Miller-Fisher syndromes are of diverse genetic lineage, serotype, and flagella type

被引:63
作者
Dingle, KE
Van den Braak, N
Colles, FM
Price, LJ
Woodward, DL
Rodgers, FG
Endtz, HP
Van Belkum, A
Maiden, MCJ
机构
[1] Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol & Infect Dis, Oxford OX1 3FY, England
[2] Erasmus Univ, Med Ctr Rotterdam, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
[3] Natl Microbiol Lab, Natl Lab Enter Pathogens, Winnipeg, MB R3E 3R2, Canada
关键词
D O I
10.1128/JCM.39.9.3346-3349.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Guillain-Barre syndrome (GBS) and Miller-Fisher syndrome (MFS) are correlated with prior infection by Campylobacter jejuni in up to 40% of cases. Nucleotide sequence-based typing of 25 C. jejuni isolates associated with neuropathy permitted robust comparisons with equivalent data from approximately 800 C. jejuni isolates not associated with neuropathy. A total of 13 genetic lineages and 20 flaA short variable region nucleotide sequences were present among the 25 isolates. A minority of isolates (4 of 25) had the flaA short variable region nucleotide sequences that were previously proposed as a marker for GBS-associated isolates. These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS.
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页码:3346 / 3349
页数:4
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