Synthesis of 1-Indanones from Benzoic Acids

被引:11
作者
Huang, Yun-Sheng [1 ]
Liu, Jian-Qiang [1 ]
Zhang, Lang-Jun [1 ]
Lu, He-Lin [1 ]
机构
[1] Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China
关键词
TOPOISOMERASE-I INHIBITORS; FRIEDEL-CRAFTS REACTION; INDANONES; DERIVATIVES; AGENTS; ANTAGONISTS;
D O I
10.1021/ie202369w
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
An improved process for the preparation of 1-indanones from various benzoic acids is described. This process involves a Friedel Crafts acylation between a substituted benzoyl chloride and ethylene, followed by an intramolecular Friedel-Crafts alkylation in the presence of aluminum chloride. The described process combines three steps into a one-pot process, is scalable, is cost-effective, and thus has a general applicability in manufacturing production of various 1-indanones.
引用
收藏
页码:1105 / 1109
页数:5
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