Synthesis of 1-Indanones from Benzoic Acids

被引：11

作者：

Huang, Yun-Sheng ^{[1
]}

Liu, Jian-Qiang ^{[1
]}

Zhang, Lang-Jun ^{[1
]}

Lu, He-Lin ^{[1
]}

机构：

[1] Guangdong Med Coll, Sch Pharm, Dongguan 523808, Peoples R China

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2012年 / 51卷 / 03期

关键词：

TOPOISOMERASE-I INHIBITORS; FRIEDEL-CRAFTS REACTION; INDANONES; DERIVATIVES; AGENTS; ANTAGONISTS;

D O I：

10.1021/ie202369w

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

An improved process for the preparation of 1-indanones from various benzoic acids is described. This process involves a Friedel Crafts acylation between a substituted benzoyl chloride and ethylene, followed by an intramolecular Friedel-Crafts alkylation in the presence of aluminum chloride. The described process combines three steps into a one-pot process, is scalable, is cost-effective, and thus has a general applicability in manufacturing production of various 1-indanones.

引用

页码：1105 / 1109

页数：5

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