New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cancer cell, SBC-3

被引：38

作者：

Ohno, T

Nagatsu, A

Nakagawa, M

Inoue, M

Li, YM

Minatoguchi, S

Mizukami, H

Fujiwara, H

机构：

[1] Gifu Univ, Sch Med, Dept Internal Med 2, Gifu 5011194, Japan

[2] Gifu Univ, Sch Med, Dept Oriental Med, Gifu 5011194, Japan

[3] Kinjogakuin Univ, Coll Pharm, Moriyama Ku, Nagoya, Aichi 4638521, Japan

[4] Aichi Gakuin Univ, Sch Pharm, Lab Med Resources, Chikusa Ku, Nagoya, Aichi 4648650, Japan

[5] Nagoya City Univ, Grad Sch Pharmaceut Sci, Lab Pharmacognosy, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 50期

关键词：

Lindera strychnifolia; Lauraceae; sesquiterpene lactone; antitumor activity;

D O I：

10.1016/j.tetlet.2005.10.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

In the present study, new sesquiterpene lactones (1) and (2) were isolated from the EtOAc soluble fraction of the water extract of Linderac Radix through bioassay-guided fractionation and isolation methods. The structure of these compounds was elucidated by spectroscopic analysis of their 2D NMR spectra, including COSY, HMBC, and HMQC techniques. Two isolates showed significant cytotoxicity against the human small cell lung cancer cell SBC-3, and lesser cytotoxicity against mouse fibroblast cell 3T3-L1. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8657 / 8660

页数：4

共 14 条

[1]

Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F.!Vill [J].