Assisted ruthenium-catalyzed C-H bond activation: Carboxylic acids as cocatalysts for generally applicable direct arylations in apolar solvents

被引：344

作者：

Ackermann, Lutz ^{[1
]}

Vicente, Ruben ^{[1
]}

Althammer, Andreas ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 11期

关键词：

D O I：

10.1021/ol800773x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalytic amounts of aromatic carboxylic acid MesCO(2)H enabled efficient ruthenium-catalyzed direct arylations in apolar solvents with unparalleled broad scope via a concerted deprotonation-metalation mechanism.

引用

页码：2299 / 2302

页数：4

共 49 条

[1] Catalytic arylation reactions by C-H bond activation with aryl tosylates [J].

Ackermann, L ;

Althammer, A ;

Born, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (16) :2619-2622

[2] Phosphine oxides as preligands in ruthenium-catalyzed arylations via C-H bond functionalization using aryl chlorides [J].

Ackermann, L .

ORGANIC LETTERS, 2005, 7 (14) :3123-3125

[3] Palladium-catalyzed direct arylations of 1,2,3-triazoles with aryl chlorides using conventional heating [J].

Ackermann, Lutz ;

Vicente, Ruben ;

Born, Robert .

ADVANCED SYNTHESIS & CATALYSIS, 2008, 350 (05) :741-748

[4]

Ackermann L, 2007, TOP ORGANOMETAL CHEM, V24, P35, DOI 10.1007/3418_2007_062

[5] [RuCl3(H2O)n]-catalyzed direct arylations with bromides as electrophiles [J].

Ackermann, Lutz ;

Althammer, Andreas ;

Born, Robert .

SYNLETT, 2007, (18) :2833-2836

[6] Ruthenium(IV) alkylidenes as precatalysts for direct arylations of Alkenes with aryl chlorides and an application to sequential catalysis [J].

Ackermann, Lutz ;

Born, Robert ;

Alvarez-Bercedo, Paula .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (33) :6364-6367

[7] Catalytic arylations with challenging substrates: From air-stable HASPO preligands to indole syntheses and C-H-bond functionalizations [J].

Ackermann, Lutz .

SYNLETT, 2007, (04) :507-526

[8] Air- and moisture-stable secondary phosphine oxides as preligands in catalysis [J].

Ackermann, Lutz .

SYNTHESIS-STUTTGART, 2006, 10 (10) :1557-1571

[9] Aryl-aryl bond formation by transition-metal-catalyzed direct arylation [J].

Alberico, Dino ;

Scott, Mark E. ;

Lautens, Mark .

CHEMICAL REVIEWS, 2007, 107 (01) :174-238

[10] Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions [J].

Angell, Yu L. ;

Burgess, Kevin .

CHEMICAL SOCIETY REVIEWS, 2007, 36 (10) :1674-1689

← 1 2 3 4 5 →