In cancer drug resistance, germline matters too

被引：13

作者：

Cheng, Emily H. ^{[1
]}

Sawyers, Charles L. ^{[2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD USA

来源：

NATURE MEDICINE | 2012年 / 18卷 / 04期

关键词：

CELL-DEATH; APOPTOSIS; BIM; INDUCTION; THERAPIES; LEUKEMIA; PROTEIN; PUMA;

D O I：

10.1038/nm.2725

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer genome sequencing projects focus exclusively on the discovery of somatic changes. A new study shows that germline alterations in the proapoptotic protein BIM can have a crucial role in how a tumor responds to treatment (pages 521-528).

引用

页码：494 / 496

页数：4

共 15 条

[1] Chronic myeloid leukemia in Asia [J].

Au, Wing Y. ;

Caguioa, Priscilla B. ;

Chuah, Charles ;

Hsu, Szu Chun ;

Jootar, Saengsuree ;

Kim, Dong-Wook ;

Kweon, Il-Young ;

O'Neil, William M. ;

Saikia, Tapan K. ;

Wang, Jianxiang .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2009, 89 (01) :14-23

[2] BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations [J].

Costa, Daniel B. ;

Halmos, Balazs ;

Kumar, Amit ;

Schumer, Susan T. ;

Huberman, Mark S. ;

Boggon, Titus J. ;

Tenen, Daniel G. ;

Kobayashi, Susumu .

PLOS MEDICINE, 2007, 4 (10) :1669-1680

[3] Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics [J].

Cragg, Mark S. ;

Kuroda, Junya ;

Puthalakath, Hamsa ;

Huang, David C. S. ;

Strasser, Andreas .

PLOS MEDICINE, 2007, 4 (10) :1681-1690

[4] Bim is a suppressor of Myc-induced mouse B cell leukemia [J].

Egle, A ;

Harris, AW ;

Bouillet, P ;

Cory, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (16) :6164-6169

[5] Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction [J].

Erlacher, Miriam ;

Labi, Verena ;

Manzl, Claudia ;

Boeck, Guenther ;

Tzankov, Alexandar ;

Haecker, Georg ;

Michalak, Ewa ;

Strasser, Andreas ;

Villunger, Andreas .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (13) :2939-2951

[6] Promoting apoptosis as a strategy for cancer drug discovery [J].

Fesik, SW .

NATURE REVIEWS CANCER, 2005, 5 (11) :876-885

[7] Converting Cancer Therapies into Cures: Lessons from Infectious Diseases [J].

Glickman, Michael S. ;

Sawyers, Charles L. .

CELL, 2012, 148 (06) :1089-1098

[8] Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas [J].

Gong, Yixuan ;

Somwar, Romel ;

Politi, Katerina ;

Balak, Marissa ;

Chmielecki, Juliann ;

Jiang, Xuejun ;

Pao, William .

PLOS MEDICINE, 2007, 4 (10) :1655-1668

[9] Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies [J].

Kim, Hyungjin ;

Rafiuddin-Shah, Mubina ;

Tu, Ho-Chou ;

Jeffers, John R. ;

Zambetti, Gerard P. ;

Hsieh, James J-D. ;

Cheng, Emily H-Y. .

NATURE CELL BIOLOGY, 2006, 8 (12) :1348-U19

[10] Roles of Bim in apoptosis of normal and Bcr-Abl-expressing hematopoietic progenitors [J].

Kuribara, R ;

Honda, H ;

Matsui, H ;

Shinjyo, T ;

Inukai, T ;

Sugita, K ;

Nakazawa, S ;

Hirai, H ;

Ozawa, K ;

Inaba, T .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (14) :6172-6183

← 1 2 →