Promoting apoptosis as a strategy for cancer drug discovery

被引：980

作者：

Fesik, SW ^{[1
]}

机构：

[1] Abbott Labs, Dept R460, Abbott Pk, IL 60064 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrc1736

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Apoptosis is deregulated in many cancers, making it difficult to kill tumours. Drugs that restore the normal apoptotic pathways have the potential for effectively treating cancers that depend on aberrations of the apoptotic pathway to stay alive. Apoptosis targets that are currently being explored for cancer drug discovery include the tumour-necrosis factor (TNF)-related apoptosis-inducing ligand ( TRAIL) receptors, the BCL2 family of anti-apoptotic proteins, inhibitor of apoptosis (IAP) proteins and MDM2.

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页码：876 / 885

页数：10

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